EXAMINE THIS REPORT ON LDN-27219 POTENTIAL THERAPEUTIC APPLICATIONS

1 especially exciting compound is LDN-27219. Although most tTG inhibitors are made to bind to the protein crosslinking Energetic website, LDN-27219 rather binds for the nucleotide binding pocket from the enzyme though it truly is in its shut-condition conformation, and stabilizes that conformation to circumvent crosslinking activity.78 Schneider et